Ульвие Гулиева

Образование:

• Азербайджанский медицинский университет — доктор медицинских наук (2001)
  
• Детская неврологическая больница — стажировка по детской неврологии (2007)
  
• Датский центр эпилепсии, Дианалунд, Дания — стажировка по детской эпилептологии и ЭЭГ (2013)
  
• Медицинский университет им. Давида Твилдиани — доктор философии (2020)
  
• Гарвардская школа общественного здравоохранения им. Т.Х. Чана — курс по ответственному проведению исследований (2024)
  
• Гарвардская медицинская школа, Детская больница Бостона — постдокторская подготовка (2024)

Опыт работы:

• Университетская больница Шлезвиг-Гольштейна, Германия - исследователь в области нейропедиатрии (2016)
• Член исследовательской группы SYNaPS (Университетский колледж Лондона – UCL) (2018-)
  
• Детская неврологическая больница - эксперт Комиссии по эпилепсии (2025-2026)
  
• Больница MediClub - невролог/нейрофизиолог (2015-)
  
• Больница Liv Bona Dea - невролог/нейрофизиолог (2026-)

Научная деятельность:

• Более 25 международных научных статей
• Публикации в журналах Nature, Brain, Annals of Neurology
  
• Презентации на европейских и региональных конгрессах (2018-2026)

• Melikova S., Mahalov Sh., Guliyeva U. et al, Status epilepticus during pregnancy. National Journal of Neurology 2017 
  
• Guliyeva U, Okur I, Dulac O, Khalilov O, Guliyeva S. Epilepsy in Biotinidase Deficiency Is Distinct from Early Myoclonic Encephalopathy. Neuropediatrics. 2018 Dec;49(6):417-418. doi: 10.1055/s-0038-1666845. Epub 2018 Jul 12. PMID: 30001564. 
  
• Salpietro V, Dixon CL, Guo H, Bello OD, Vandrovcova J, Efthymiou S, Maroofian R, Guliyeva U. et al, AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders. Nat Commun. 2019 Jul 12;10(1):3094. doi: 10.1038/s41467-019-10910-w. PMID: 31300657; PMCID: PMC6626132. 
  
• Chelban V, Wilson MP, Warman Chardon J, Vandrovcova J, Guliyeva U, et al, PDXK mutations cause polyneuropathy responsive to pyridoxal 5'-phosphate supplementation. Ann Neurol. 2019 Aug;86(2):225-240. doi: 10.1002/ana.25524. Epub 2019 Jul 1. PMID: 31187503; PMCID: PMC6772106. 
  
• Ulviyya Guliyeva, Nana Nino Tatishvili, Rauan Kaiyrzhanov, Chapter: Rolandic epilepsy : Self limited epilepsy with centrotemporal spikes, IntechOpen2021, doi:10.5772/intechopen.96148 
  
• Kurian MA, Kaiyrzhanov R, Allahyarova P, Guliyeva U, Gulieva S, Salayev K, Mursalova A, Ferla MP, Houlden H, Cardoso F. Commentary: GM1 Gangliosidosis Type III Associated Parkinsonism. Mov Disord Clin Pract. 2021 Sep 3;8(Suppl 1):S24-S25. doi: 10.1002/mdc3.13301. PMID: 34514041; PMCID: PMC8414508. 
  
• Kaiyrzhanov R, Guliyeva U, Gulieva S, Salayev K, Mursalova A, Allahyarova P, Ferla MP, Houlden H. GM1-Gangliosidosis Type III Associated Parkinsonism. Mov Disord Clin Pract. 2021 Sep 3;8(Suppl 1):S21-S23. doi: 10.1002/mdc3.13289. PMID: 34514040; PMCID: PMC8414511. 
  
• Marafi D, Fatih JM, Kaiyrzhanov R, Ferla MP, Gijavanekar C, Al-Maraghi A, Guliyeva U, et al, Biallelic variants in SLC38A3 encoding a glutamine transporter cause epileptic encephalopathy. Brain. 2021 Oct 4:awab369. doi: 10.1093/brain/awab369. Epub ahead of print. PMID: 34605855.
  
• Calì E, Lin SJ, Rocca C, Sahin Y, Al Shamsi A, El Chehadeh S, Chaabouni M, Mankad K, Galanaki E, Efthymiou S, Sudhakar S, Athanasiou-Fragkouli A, Çelik T, Narlı N, Bianca S, Murphy D, De Carvalho Moreira FM; Guliyeva U, Maroofian R, Salpietro V, Houlden H. A homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease. Genet Med. 2022 Oct;24(10):2194 2203. doi: 10.1016/j.gim.2022.07.013. Epub 2022 Aug 24. PMID: 36001086. 
  
• Salayev K, Rocca C, Kaiyrzhanov R, Guliyeva U, Guliyeva S, Mursalova A, Rahman F, Anwar N, Zafar F, Jan F, Rana N, Maqbool S; SYNAPS Study Group; QUEEN SQUARE Genomics, Efthymiou S, Houlden H. AP4B1 associated hereditary spastic paraplegia: Expansion of clinico-genetic  phenotype and geographic range. Eur J Med Genet. 2022 Nov;65(11):104620. doi: 10.1016/j.ejmg.2022.104620. Epub 2022 Sep 16. PMID: 36122674. 
  
• Kaiyrzhanov R, Rocca C, Suri M, Gulieva S, Zaki MS, Henig NZ, Siquier K, Guliyeva U, Mounir SM, Marom D, Allahverdiyeva A, Megahed H, van Bokhoven H, Cantagrel V, Rad A, Pourkeramti A, Dehghani B, Shao DD, Markus-Bustani K, Sofrin-Drucker E, Orenstein N, Salayev K, Arrigoni F, Houlden H, Maroofian R. Biallelic loss of EMC10 leads to mild to severe intellectual disability. Ann Clin Transl Neurol. 2022 Jul;9(7):1080-1089. doi: 10.1002/acn3.51602. Epub 2022 Jun 9. PMID: 35684946; PMCID: PMC9268894. 
  
• Christensen MB, Levy AM, Mohammadi NA, Niceta M, Kaiyrzhanov R, Dentici ML, Al Alam C, Alesi V, Benoit V, Bhatia KP, Bierhals T, Boßelmann CM, Buratti J, Callewaert B, Ceulemans B, Charles P, De Wachter M, Dehghani M, D'haenens E, Doco-Fenzy M, Geßner M, Gobert C, Guliyeva U, Haack TB, Hammer TB, Heinrich T, Hempel M, Herget T, Hoffmann U, Horvath J, Houlden H, Keren B, Kresge C, Kumps C, Lederer D, Lermine A, Magrinelli F, Maroofian R, Vahidi Mehrjardi MY, Moudi M, Müller AJ, Oostra AJ, Pletcher BA, Ros Pardo D, Samarasekera S, Tartaglia M, Van Schil K, Vogt J, Wassmer E, Winkelmann J, Zaki MS, Zech M, Lerche H, Radio FC, Gomez-Puertas P, Møller RS, Tümer Z. Biallelic variants in ZNF142 lead to a syndromic neurodevelopmental disorder. Clin Genet. 2022 Aug;102(2):98-109. doi: 10.1111/cge.14165. Epub 2022 Jun 8. PMID: 35616059; PMCID: PMC9546172. 
  
• Marafi D, Fatih JM, Kaiyrzhanov R, Ferla MP, Gijavanekar C, Al-Maraghi A, Liu N, Sites E, Alsaif HS, Al-Owain M, Zakkariah M, El-Anany E, Guliyeva U, Guliyeva S, Gaba C, Haseeb A, Alhashem AM, Danish E, Karageorgou V, Beetz C, Subhi AA, Mullegama SV, Torti E, Sebastin M, Breilyn MS, Duberstein S, Abdel-Hamid MS, Mitani T, Du H, Rosenfeld JA, Jhangiani SN, Coban Akdemir Z, Gibbs RA, Taylor JC, Fakhro KA, Hunter JV, Pehlivan D, Zaki MS, Gleeson JG, Maroofian R, Houlden H, Posey JE, Sutton VR, Alkuraya FS, Elsea SH, Lupski JR. Biallelic variants in SLC38A3 encoding a glutamine transporter cause epileptic encephalopathy. Brain. 2022 Apr 29;145(3):909924. doi: 10.1093/brain/awab369. PMID: 34605855; PMCID: PMC9050560. 
  
• Saida K, Maroofian R, Sengoku T, Mitani T, Pagnamenta AT, Marafi D, Zaki MS, O'Brien TJ, Karimiani EG, Kaiyrzhanov R, Takizawa M, Ohori S, Leong HY, Akay G, Galehdari H, Zamani M, Romy R, Carroll CJ, Toosi MB, Ashrafzadeh F, Imannezhad S, Malek H, Ahangari N, Tomoum H, Gowda VK, Srinivasan VM, Murphy D, Dominik N, Elbendary HM, Rafat K, Yilmaz S, Kanmaz S, Serin M, Krishnakumar D, Gardham A, Maw A, Rao TS, Alsubhi S, Srour M, Buhas D, Jewett T, Goldberg RE, Shamseldin H, Frengen E, Misceo D, Strømme P, Magliocco Ceroni JR, Kim CA, Yesil G, Sengenc E, Guler S, Hull M, Parnes M, Aktas D, Anlar B, Bayram Y, Pehlivan D, Posey JE, Alavi S, Madani Manshadi SA, Alzaidan H, Al-Owain M, Alabdi L, Abdulwahab F, Sekiguchi F, Hamanaka K, Fujita A, Uchiyama Y, Mizuguchi T, Miyatake S, Miyake N, Elshafie RM, Salayev K, Guliyeva U, Alkuraya FS, Gleeson JG, Monaghan KG, Langley KG, Yang H, Motavaf M, Safari S, Alipour M, Ogata K, Brown AEX, Lupski JR, Houlden H, Matsumoto N. Brain monoamine vesicular transport disease caused by homozygous SLC18A2 variants: A study in 42 affected individuals. Genet Med. 2023 Jan;25(1):90-102. doi: 10.1016/j.gim.2022.09.010. Epub 2022 Oct 31. PMID: 36318270. 
  
• Salpietro V, Maroofian R, Zaki MS, Wangen J, Ciolfi A, Barresi S, Efthymiou S, Lamaze A, Aughey GN, Al Mutairi F, Rad A, Rocca C, Calì E, Accogli A, Zara F, Striano P, Mojarrad M, Tariq H, Giacopuzzi E, Taylor JC, Oprea G, Skrahina V, Rehman KU, Abd Elmaksoud M, Bassiony M, El Said HG, Abdel-Hamid MS, Al Shalan M, Seo G, Kim S, Lee H, Khang R, Issa MY, Elbendary HM, Rafat K, Marinakis NM, Traeger-Synodinos J, Ververi A, Sourmpi M, Eslahi A, Khadivi Zand F, Beiraghi Toosi M, Babaei M, Jackson A; SYNAPS Study Group(Guliyeva U); Bertoli-Avella A, Pagnamenta AT, Niceta M, Battini R, Corsello A, Leoni C, Chiarelli F, Dallapiccola B, Faqeih EA, Tallur KK, Alfadhel M, Alobeid E, Maddirevula S, Mankad K, Banka S, Ghayoor-Karimiani E, Tartaglia M, Chung WK, Green R, Alkuraya FS, Jepson JEC, Houlden H. Bi allelic genetic variants in the translational GTPases GTPBP1 and GTPBP2 cause a distinct identical neurodevelopmental syndrome. Am J Hum Genet. 2024 Jan 4;111(1):200-210. doi: 10.1016/j.ajhg.2023.11.012. Epub 2023 Dec 20. PMID: 38118446; PMCID: PMC10806450. 
  
• Clara-Hwang A, Stefani S, Lau T, Scala M, Aynekin B, Bernardo P, Madia F, Bakhtadze S, Kaiyrzhanov R, Maroofian R, Zara F, Srinivasan VM, Gowda V, Guliyeva U, Montavont A, Poulat AL, Güleç A, Berger C, Ville DM, de Bellescize J, Cabet S, Wonneberger A, Schulz A, Rodriguez-Palmero A, Chatron N, Lesca G, Per H, Goel H, Brown J, Frey T, Steindl K, Rauch A, Severino M, Houlden H, Nicolaides P, Striano P, Efthymiou S. Expanding the Mutational Landscape and Clinical Phenotype of CHD2-Related Encephalopathy. Neurol Genet. 2024 Jul 11;10(4):e200168. doi: 10.1212/NXG.0000000000200168. PMID: 39035822; PMCID: PMC11259532. 
  
• Melikishvili G, Striano P, Shojeinia E, Gachechiladze T, Kurua E, Tabatadze N, Melikishvili M, Koniashvili O, Khachiashvili G, Epitashvili N, Rimma G, Belyaev O, Tomenko T, Kharytonov V, Guliyeva U, Esguerra CV, Crawford AD, Dulac O. Effectiveness of add-on acetazolamide in children with drug-resistant CHD2 related epilepsy and in a zebrafish CHD2 model. Epilepsia Open. 2024 Aug 24. doi: 10.1002/epi4.13034. Epub ahead of print. PMID: 39180515. 
  
• Kaiyrzhanov R, Zharkinbekova N, Guliyeva U, Ganieva M, Tavadyan Z, Gachechiladze T, Salayev K, Guliyeva S, Isayan M, Kekenadze M, Sukhudyan B, Gevorgyan A, Hakobyan A, Ibadova R, Tabatadze N, Kurua E, Shatirishvili T, Yerkhojayeva N, Koneev K, Zhumakhanov D, Mukushev A, Jaxybayeva A, Nauryzbayeva A, Isrofilov M, Badalova S, Zeyniyeva N, Hajiyeva I, Alakbarov L, Zeynalova A, Chelban V, Vandrovcova J, Turchetti V, Murphy D, Efthymiou S, Alavi S, Mohammad R, Tkemaladze T, Shashkin C, Tatishvili NN, Beridze M, Khachatryan SG, Melikishvili G, Hardy J, Maroofian R, Houlden H. Elucidating the genomic basis of rare pediatric neurological diseases in Central Asia and Transcaucasia. Nat Genet. 2024 Nov 22. doi: 10.1038/s41588-024-02016-x. Epub ahead of print. PMID: 39578646. 
  
• Salayev K, Guliyeva U, Guliyeva S, Kaiyrzhanov R, Aslanova U, Hajiyeva N, Houlden H, Munir K. Attitudes of parents of children with rare neurological disorders towards clinical genetic testing. J Community Genet. 2025 Jul 4. doi: 10.1007/s12687-025-00815-1. Epub ahead of print. PMID: 40613954. 
  
• Alabdi L, Altuwaijri N, Zhu JY, Efthymiou S, Lee H, Duan J, Salem I, Yu P, Abdullah NL, Alzahrani F, Xu Q, Felemban MM, Alfaifi A, Rahman F, Christoforou M, Maqbool S, Martinez-Agosto JA, Alsaif HS, Hashem M, Helaby R, Alsulaiman A; SYNaPS Study Group- Guliyeva.U; Queen Square Genomics; Maroofian R, Houlden H, Arold ST, Ibrahim LA, Han Z, Alkuraya FS. SLK is mutated in individuals with a neurodevelopmental disorder. EBioMedicine. 2025 Jun;116:105725. doi: 10.1016/j.ebiom.2025.105725. Epub 2025 May 9. PMID: 40347834; PMCID: PMC12139437. 
  
• Buchert R, Burkhalter MD, Huridou C, Sofan L, Roser T, Cremer K, Alvi JR, Efthymiou S, Froukh T, Gulieva S, Guliyeva U, Hamdallah M, Holder Espinasse M, Kaiyrzhanov R, Klingler D, Koko M, Matthies L, Park J, Sturm M, Velic A, Spranger S, Sultan T, Engels H, Lerche H, Houlden H, Pagnamenta AT, Borggraefe I, Weber Y, Bonnen PE, Maroofian R, Riess O, Weber JJ, Philipp M, Haack TB. Bi-allelic KICS2 mutations impair KICSTOR complex mediated mTORC1 regulation, causing intellectual disability and epilepsy. Am J Hum Genet. 2025 Feb 6;112(2):374-393. doi: 10.1016/j.ajhg.2024.12.019. Epub 2025 Jan 16. PMID: 39824192; PMCID: PMC11866974. 
  
• Akçimen F, Alvarez Jerez P, Guliyeva U, Lee J, Malik L, Baker B, Salayev K, Guliyeva S, Billingsley KJ, Houlden H, Singleton AB, Blauwendraat C, Bandres Ciga S, Kaiyrzhanov R. A CGG Repeat Expansion in CSNK1E Associated with Progressive Myoclonic Epilepsy with Incomplete Penetrance. Mov Disord. 2025 Nov;40(11):2469-2475. doi: 10.1002/mds.30326. Epub 2025 Aug 1. PMID: 40751262; PMCID: PMC12661629. 
  
• Guliyeva U, Tatishvili NN, Salayev K, Kaiyrzhanov R, Hiz S, Munir K, Williams DA, Isayev C, Guliyeva S, Houlden H, Dulac O. Consanguinity and treatment strategy determine seizure outcome and mortality in infantile epileptic spasms syndrome in Azerbaijan. Seizure. 2025 Nov;132:125-132. doi: 10.1016/j.seizure.2025.09.001. Epub 2025 Sep 3. PMID: 40967019. 
  
• Kayhan G, Tany R, Maroofian R, Serdaroğlu E, Kurumiya E, Tran DP, Wakasugi-Masuho H, Thomsen M, Salayev K, Kaiyrzhanov R, Badalova S, Guliyeva U, Kareem A, Bauer P, Zifarelli G, Houlden H, Lohmann K, Kitao A, Mulayim MF, Masuho I. DRD1-driven infantile dystonia: towards a mechanism informed framework for GPCR receptoropathies. Brain. 2026 Apr 9:awag128. doi: 10.1093/brain/awag128. Epub ahead of print. PMID: 41966088. 
  
• Günaya Ç, Yılmazbilek İ, Soydemir D, Sarıkaya Uzan G, Özsoy Ö, Yeşilmen MC, Guliyeva U, Polat Kalafatçılar İ, Yiş U, Hız Kurul S, Karaca E. The role of DHH motifs in PRUNE1 gene on ion channels: A new insight into epilepsy pathogenesis. Epilepsy Res. 2026 Apr 8;224:107798. doi: 10.1016/j.eplepsyres.2026.107798. Epub ahead of print. PMID: 41980489.